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Breldigital > Blog > ds > Select the best conditions for the reactions
ds

Select the best conditions for the reactions

By John Published November 7, 2022
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Concepts and reason
In general, primary alkyl halides undergo image reactions with strong nucleophiles and tertiary alkyl halides undergo image reaction with weak nucleophiles.

Fundamentals
Strong nucleophile is required for image reaction and these reactions are occurred in polar aprotic solvents (i.e. DMSO, DMF etc.).
Weak nucleophile is required for image reaction. If a nucleophile is strong then there is a chance for the E2 product formation.

Answer:

Part a
The reaction is,

image

image.jpg766×248 28.1 KB

 

Explanation:
Here, sodium methoxide acts as a strong nucleophile and DMSO is polar aprotic solvent. 1-bromo-3-methylbutane reacts with image to form 1-methoxy-3-methylbutane.

Part b
The reaction is,

image

image.png703×179 10 KB

 

image

Explanation:
Methanol is weak nucleophile and it reacts with 2-bromo-2-methylbutane to form 2-methoxy-2-methylbutane.

TAGGED: Select the best conditions for the reactions
John November 7, 2022 November 7, 2022

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